Round UUID: 41111d68-9394-4ae2-91c4-e92fb0cd29d3
Prompt:
### Enhanced Prediction Rules for Reducing False Predictions in Entity Classification ###
In this iteration, the rules are designed to address recurring inaccuracies observed in prior datasets, ensuring that the thresholds and overrides are specific, holistic, and context-sensitive. The emphasis is on minimizing both false positives and false negatives.
#### General Rules Across All Histogen_Complexes (Apply in Priority Order):
1. **Critical Combined Genetic Class Matches Threshold:**
- **Predict Failure** if `Genetic_Class_A_Matches + Genetic_Class_B_Matches` < 3, irrespective of other features.
- **Predict Success** only if:
a. `Combined Genetic_Class Matches` >= 6.
b. Both `Treatment_Months` > 80 and `TcQ_mass` > 50,000.
2. **Adjusted TcQ_mass Overrides:**
- **Predict Failure** if `TcQ_mass` > 180,000 and `Combined Genetic_Class Matches` < 5, unless `Histogen_Complex`-specific rules override this.
- **Predict Success** if `TcQ_mass` >= 200,000, provided `Genetic_Class_A_Matches` >= 3 and `Genetic_Class_B_Matches` >= 3, regardless of `Treatment_Months`.
3. **Minimum Treatment_Months Override:**
- **Predict Failure** universally if `Treatment_Months` < 20, notwithstanding Genetic_Class Matches and TcQ_mass values.
#### Rules Specific to Histogen_Complex Types:
- **For Histogen_Complex = 'Beta':**
1. **Failure Triggered by Low Genetic Classes:** Predict Failure if `Genetic_Class_A_Matches + Genetic_Class_B_Matches` <= 5, regardless of `TcQ_mass`.
2. **Success Triggered by High TcQ_mass:** Predict Success if:
a. `TcQ_mass` > 50,000 and both `Genetic_Class_A_Matches` >= 3 and `Genetic_Class_B_Matches` >= 3.
b. `Treatment_Months` > 100.
- **For Histogen_Complex = 'Delta' or 'Omicron':**
1. **Failure Condition for Low Matches:** Predict Failure if `Genetic_Class_A_Matches + Genetic_Class_B_Matches` < 6 and either:
a. `TcQ_mass` < 25,000.
b. `Treatment_Months` <= 60.
2. **Override for High Matches and Long Treatment Periods:** Predict Success if:
a. `Combined Genetic_Class Matches` >= 7.
b. `Treatment_Months` >= 90 and `TcQ_mass` >= 40,000.
#### Special Rules for Specific Cohorts:
- **Cohort = 'Delhi':**
- Always **Predict Success** if `TcQ_mass` > 200,000, even when Genetic_Class Matches are below typical thresholds.
- **Other Cohorts:**
- Adhere strictly to general threshold rules, with no overrides for high `TcQ_mass` unless `Treatment_Months` > 90.
#### Gender-Specific Adjustments (for Sex = Female):
- **Failure Bias:** Predict Failure if:
a. Both `Genetic_Class_A_Matches` < 3 and `Genetic_Class_B_Matches` < 3.
b. `TcQ_mass` is between 25,000-40,000 and `Treatment_Months` <= 80.
- **Success Overrides:** Predict Success if:
a. `TcQ_mass` > 60,000 and combined Genetic_Class Matches >= 7.
b. `Treatment_Months` > 100, regardless of TcQ_mass values.
#### Final Catch-All Rule:
- Default to **Predict Failure** if an entry does not explicitly meet any outlined Success criteria. However, a borderline success prediction should apply if:
a. `Treatment_Months` > 90.
b. Genetic_Class thresholds are within 1 match of success cutoff (e.g., 5 matches when 6 is required).
c. `TcQ_mass` > 75,000.