Round UUID: a52aca91-0c3e-40f3-917f-7475ddec9df5
Prompt:
Use the following comprehensive and adaptive decision rules to predict success or failure: 1. Complex-Specific Prediction Framework: Delta Complex Prediction Rules: - Failure More Likely If: * TcQ_mass between 6000 and 20000 * Treatment_Months < 60 or > 120 * Genetic_Class_A_Matches ≥ 2 * Cohort is Melbourne or Delhi (additional risk factor) - Success Indicators: * TcQ_mass > 40000 * Treatment_Months between 80-150 * Genetic_Class_A_Matches ≤ 1 * Male subjects with higher Genetic_Class_B_Matches Omicron Complex Prediction Rules: - Failure More Likely If: * TcQ_mass between 10000 and 30000 * Treatment_Months < 75 or > 135 * Genetic_Class_B_Matches: - Females: > 1 - Males: > 2 - Success Indicators: * TcQ_mass > 50000 * Treatment_Months between 90-180 * Balanced Genetic_Class_Matches * Male subjects with consistent treatment duration Beta Complex Prediction Rules: - Failure More Likely If: * TcQ_mass between 30000 and 100000 * Treatment_Months outside 90-180 range * Genetic_Class_A_Matches > 2 * Genetic_Class_B_Matches unbalanced - Success Indicators: * TcQ_mass > 100000 * Treatment_Months > 120 * Higher total Genetic_Class_Matches * Consistent performance across cohorts 2. Advanced Scoring Mechanism: - Implement a weighted scoring system considering: * Complex-specific TcQ_mass ranges * Treatment duration normalized by sex * Genetic match quality and balance * Subtle cohort performance variations 3. Final Prediction Strategy: - Calculate cumulative probability score - Apply probabilistic thresholds - Consider marginal cases with nuanced scoring - Prioritize contextual evidence over rigid rules Make a binary prediction: Success or Failure, based on these comprehensive, context-aware rules.