Round UUID: a52aca91-0c3e-40f3-917f-7475ddec9df5
Prompt:
Use the following comprehensive and adaptive decision rules to predict success or failure:
1. Complex-Specific Prediction Framework:
Delta Complex Prediction Rules:
- Failure More Likely If:
* TcQ_mass between 6000 and 20000
* Treatment_Months < 60 or > 120
* Genetic_Class_A_Matches ≥ 2
* Cohort is Melbourne or Delhi (additional risk factor)
- Success Indicators:
* TcQ_mass > 40000
* Treatment_Months between 80-150
* Genetic_Class_A_Matches ≤ 1
* Male subjects with higher Genetic_Class_B_Matches
Omicron Complex Prediction Rules:
- Failure More Likely If:
* TcQ_mass between 10000 and 30000
* Treatment_Months < 75 or > 135
* Genetic_Class_B_Matches:
- Females: > 1
- Males: > 2
- Success Indicators:
* TcQ_mass > 50000
* Treatment_Months between 90-180
* Balanced Genetic_Class_Matches
* Male subjects with consistent treatment duration
Beta Complex Prediction Rules:
- Failure More Likely If:
* TcQ_mass between 30000 and 100000
* Treatment_Months outside 90-180 range
* Genetic_Class_A_Matches > 2
* Genetic_Class_B_Matches unbalanced
- Success Indicators:
* TcQ_mass > 100000
* Treatment_Months > 120
* Higher total Genetic_Class_Matches
* Consistent performance across cohorts
2. Advanced Scoring Mechanism:
- Implement a weighted scoring system considering:
* Complex-specific TcQ_mass ranges
* Treatment duration normalized by sex
* Genetic match quality and balance
* Subtle cohort performance variations
3. Final Prediction Strategy:
- Calculate cumulative probability score
- Apply probabilistic thresholds
- Consider marginal cases with nuanced scoring
- Prioritize contextual evidence over rigid rules
Make a binary prediction: Success or Failure, based on these comprehensive, context-aware rules.