Round 85

Round UUID: bccf9401-b2e9-4b1d-9b27-63d2cabccdfa

Prompt:

Predict treatment outcome using these comprehensive decision rules:

1. Histogen_Complex Specific Scoring System:

Delta Complex:
- Base Failure Risk Factors:
  a) If Treatment_Months > 90 AND TcQ_mass < 10000: +2 Failure Points
  b) If Genetic_Class_B_Matches > 2: +1 Failure Point
  c) If Treatment_Months < 60 AND TcQ_mass < 8000: +2 Failure Points

- Mitigating Success Factors:
  a) If Genetic_Class_A_Matches > 1: -1 Failure Point
  b) If TcQ_mass > 20000: -2 Failure Points
  c) If Cohort is Delhi: -1 Failure Point

Beta Complex:
- Base Success Indicators:
  a) If TcQ_mass > 50000: +3 Success Points
  b) If Treatment_Months between 100-140: +2 Success Points
  c) If Genetic_Class_A_Matches > 1: +1 Success Point

- Failure Risk Factors:
  a) If Treatment_Months > 150: +2 Failure Points
  b) If Genetic_Class_B_Matches > 2: +1 Failure Point
  c) If TcQ_mass < 15000: +1 Failure Point

Omicron Complex:
- Base Outcome Determination:
  a) If Treatment_Months > 120 AND TcQ_mass < 15000: +2 Failure Points
  b) If TcQ_mass > 30000: +2 Success Points
  c) If Genetic_Class_A_Matches > 1: +1 Success Point

2. Final Outcome Calculation:
- Tally total Failure/Success Points
- Apply Sex-based modifier:
  * Female: -0.5 Failure Points
  * Male: +0.5 Failure Points

3. Decision Threshold:
- If Total Points > 2: Predict FAILURE
- If Total Points < -2: Predict SUCCESS
- If Points between -2 and 2: Requires further investigation

4. Confidence Modifiers:
- High genetic match diversity increases prediction confidence
- Cohort variations (Melbourne/Delhi/Lisbon) provide additional context
- Extreme TcQ_mass values (very high or very low) warrant closer scrutiny

Evaluation Process:
1. Identify Histogen_Complex
2. Calculate point-based risk assessment
3. Apply sex and cohort modifiers
4. Make final probabilistic prediction